Very angered, desperate and disillusioned, Thrax kills both Cramp and Bruiser in an explosion, heading off to finish things as a lone wolf.
As Thrax prepares to get back on schedule, Bruiser suggests they incubate for a while as they are a few in numbers (which would mean Thrax won't be able to break his record). Yet, the virus has survived and is hiding in a toenail with Joe Cramp and Bruiser left. After a brief battle, the zit is destroyed in the explosion of a medicine grenade, killing most of Thrax's gang and seemingly Thrax himself as well. When Ozzy is caught, Drix barges in just as Thrax was about to incinerate him. There, he discovers that Thrax is a deadly virus and serial killer whose purpose is to kill each person he contaminates faster than the last and is now planning to murder Frank within 48 hours (which is faster than any virus has killed) so that he will be a famous killer and get his own chapter in the medical books. Jones uses his body-altering abilities to pass as a germ and infiltrates a meeting of Thrax and his thugs inside the zit to get in on what is going on. However, Drix sticks with Ozzy and they learn from flu vaccine informant, Chill, that Thrax is at a zit nightclub where there is a meeting being held there. Even after Jones reveals that he saw Thrax as the cause, the incompetent and election-obsessed Mayor Phlegmming (who is to blame for Frank's disastrous lifestyle) dismisses his warnings and states it to be nothing more than a "common cold". Before making his escape, Ozzy sees Thrax before rescuing Drix from the mucus overflow of the nose. Ozzy and Drix investigate the nose dam where Thrax and his gang destroy the dam to make it look like a common cold. The titular primary protagonist is Osmosis "Ozzy" Jones, one of Frank's white blood cells who was demoted from the police after he activated the emergency evacuation (i.e., throwing up), to get rid of germs from polluted oysters, which was seen as "unnecessary force" gets reluctantly teamed up with a rule-abiding cold pill named Drix (Drixenol) to investigate the throat inflammation (in fact Thrax's doing) with the latter unknowingly covering up the evidence of Thrax's arrival, and they discover that something far more dangerous is going on. There, he quickly takes control of the germs' gang by killing their leader Scabies and plans to take advantage of Frank's poor health condition to operate undetected.
Thrax casually murders the two witnesses of his arrival, uses their boat to go down Frank's throat which he also causes a throat inflammation and goes to the germs' headquarters in Frank's armpit.
By doing so, he infiltrates the City of Frank, a huge metropolis inside Frank's body in which each of his body cells is living a life identical to that of humans, with white blood cells as cops and germs as criminals. Before the events of the film, Thrax killed three victims which was a little girl who didn't like to wash her hands in 3 weeks, then killed a nice lady in 6 days and then an old man in 72 hours.īy the beginning of the film, Thrax enters the body of Frank DeTorre, a zookeeper without the slightest regard for hygiene and health, when the latter eats an egg that was just spat by a chimp onto the ground.
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